Watch the video above and install SKSE64 (version 2.0.15 or later).
Solution 2: Reinstall Nexus Mod Manager Uninstalling: First of all, ensure you are signed in with an admin account as you won’t have the option to erase programs utilizing some other account. (Do not uninstall the mod, just deactivate the esp.) No matter what a user does, it does not open.